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KMID : 0861020130280050079
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Korea Journal of Herbology
2013 Volume.28 No. 5 p.79 ~ p.85
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The study on pharmacologic activation as cosmetic material of Sanguisorbae radix
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Jang Young-Ah
Kim Young-Hun
Shin Jae-Cheon
Han Sang-Ik
Lee Jin-Tae
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Abstract
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Objectives: This study was aimed at producing emulsion by using butanol fractions of Sanguisorbae radix(SRA-B) which have high antioxidative and anti-inflammatory actions, and then evaluating stabilities of the emulsion.
Methods: We measured antioxidant efficacy of SRA-B by using DPPH assay. Also, we checked the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) by using the Western blot to evaluate the anti-inflammatory effects of SRA-B3. We prepared emulsion containing SRA-B3(E-SRA-B3) and analysed its particle size distribution under a microscope. Also, we performed the test for stability of the emulsion.
Results: SRA-B3 showed the highest efficacy in electronic donating abilities` activity. The Western blot`s results indicated that the protein expression`s amount of iNOS and COX-2 in macrophage stimulated by LPS were reduced by SRA-B3 treatment. The average particle size of E-SRA-B3 was 5~6㎛ in diameter and was 6.7㎛ in a view of the particle distribution. For a period of a observation, E-SRA-B3 has not made particular changes with storage temperature. It was observed that E-SRA-B3 could preserve its stable condition without a particular difference of viscosity during 28 days.
Conclusions: From the above results, it was confirmed that SRA-B3 has potentiality enough to be applied to industrialization and could be utilized as antioxidative natural materials and anti-inflammatory cosmetics.
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KEYWORD
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Sanguisorbae radix, anti-inflammation, emulsion, stability
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